Drug interactions
Nalbuphine + Pimozide
Severity: Moderate
Nalbuphine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may increase drowsiness and impair psychomotor function when taken together. Pimozide also carries a QT-prolonging risk and requires careful monitoring, though nalbuphine is not known to add to this significantly.
What this interaction means in plain words
Nalbuphine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nalbuphine belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor for oversedation and reduce the dose if it occurs. Continue routine ECG and electrolyte monitoring for pimozide therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Nalbuphine with Pimozide?
MediHelp rates the interaction as moderate. Nalbuphine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may increase drowsiness and impair psychomotor function when taken together. Pimozide also carries a QT-prolonging risk and requires careful monitoring, though nalbuphine is not known to add to this significantly.
How serious is the interaction between Nalbuphine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the dose if it occurs. Continue routine ECG and electrolyte monitoring for pimozide therapy.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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