Drug interactions
Nalbuphine + Quazepam
Severity: Major
Nalbuphine and Quazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic, and with an opioid it markedly increases sedation and the risk of respiratory depression. Profound sedation, coma or death have been reported with opioid and benzodiazepine combinations.
What this interaction means in plain words
Nalbuphine and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through opioid receptor activity and enhanced GABA-A signalling.
What to do
Avoid unless no alternative exists; use the lowest doses for the shortest time and monitor sedation and respiratory rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Nalbuphine with Quazepam?
MediHelp rates the interaction as major. Nalbuphine and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quazepam is a long-acting benzodiazepine hypnotic, and with an opioid it markedly increases sedation and the risk of respiratory depression. Profound sedation, coma or death have been reported with opioid and benzodiazepine combinations.
How serious is the interaction between Nalbuphine and Quazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless no alternative exists; use the lowest doses for the shortest time and monitor sedation and respiratory rate.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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