Drug interactions
Nalbuphine + Scullcap
Severity: Minor
Nalbuphine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is a herb with traditional sedative use and may add to nalbuphine drowsiness. Clinical evidence is scant.
What this interaction means in plain words
Nalbuphine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive sedation from herbal constituents acting on GABAergic pathways.
What to do
Advise the patient to report excessive drowsiness and avoid driving if affected; stop the herb if sedation is problematic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Nalbuphine with Scullcap?
MediHelp rates the interaction as minor. Nalbuphine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is a herb with traditional sedative use and may add to nalbuphine drowsiness. Clinical evidence is scant.
How serious is the interaction between Nalbuphine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to report excessive drowsiness and avoid driving if affected; stop the herb if sedation is problematic.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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