Drug interactions
Nalbuphine + Triclofos
Severity: Moderate
Nalbuphine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and with nalbuphine it can cause additive sedation and respiratory depression. The effect is most relevant in children, older adults and those with respiratory compromise.
What this interaction means in plain words
Nalbuphine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and the GABAergic sedative action of trichloroethanol.
What to do
Use reduced doses of each drug and observe the patient until sedation resolves. Monitor respiratory rate and oxygen saturation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Nalbuphine with Triclofos?
MediHelp rates the interaction as moderate. Nalbuphine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and with nalbuphine it can cause additive sedation and respiratory depression. The effect is most relevant in children, older adults and those with respiratory compromise.
How serious is the interaction between Nalbuphine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses of each drug and observe the patient until sedation resolves. Monitor respiratory rate and oxygen saturation.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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