Drug interactions
Nalbuphine + Valerian
Severity: Minor
Nalbuphine and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has mild sedative properties and may add to nalbuphine drowsiness. The clinical effect is generally modest.
What this interaction means in plain words
Nalbuphine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression, likely via GABAergic activity of valerian.
What to do
Counsel on additive drowsiness and avoid driving if sedated. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Nalbuphine with Valerian?
MediHelp rates the interaction as minor. Nalbuphine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian has mild sedative properties and may add to nalbuphine drowsiness. The clinical effect is generally modest.
How serious is the interaction between Nalbuphine and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive drowsiness and avoid driving if sedated. No dose change is usually needed.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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