Drug interactions
Nalbuphine + Zotepine
Severity: Moderate
Nalbuphine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so combined use can lead to marked drowsiness and impaired psychomotor performance. Hypotension and respiratory depression are possible.
What this interaction means in plain words
Nalbuphine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and antipsychotic histamine, adrenergic and other receptor blockade.
What to do
Use the lowest effective nalbuphine dose and monitor sedation and blood pressure. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Nalbuphine with Zotepine?
MediHelp rates the interaction as moderate. Nalbuphine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so combined use can lead to marked drowsiness and impaired psychomotor performance. Hypotension and respiratory depression are possible.
How serious is the interaction between Nalbuphine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nalbuphine dose and monitor sedation and blood pressure. Advise patients to avoid driving and alcohol.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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