Drug interactions
Naldemedine + Propranolol
Severity: Minor
Naldemedine and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a P-glycoprotein substrate, and P-gp inhibitors can raise its exposure. Propranolol is not a recognized clinically meaningful P-gp inhibitor, so any effect is likely small.
What this interaction means in plain words
Naldemedine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Propranolol belongs to Cardiovascular.
Why it happens
Possible weak P-glycoprotein inhibition by propranolol could modestly increase naldemedine absorption; this is not well established.
What to do
No dose change is needed; monitor for gastrointestinal adverse effects such as abdominal pain and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Propranolol?
MediHelp rates the interaction as minor. Naldemedine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a P-glycoprotein substrate, and P-gp inhibitors can raise its exposure. Propranolol is not a recognized clinically meaningful P-gp inhibitor, so any effect is likely small.
How serious is the interaction between Naldemedine and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for gastrointestinal adverse effects such as abdominal pain and diarrhea.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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