Drug interactions
Naldemedine + Ulipristal
Severity: Minor
Naldemedine and Ulipristal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal may inhibit P-glycoprotein and raise naldemedine concentrations. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Naldemedine and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by ulipristal reduces naldemedine efflux.
What to do
Monitor for abdominal pain and diarrhea; no dose adjustment is usually needed after a single ulipristal dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Ulipristal?
MediHelp rates the interaction as minor. Naldemedine and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ulipristal may inhibit P-glycoprotein and raise naldemedine concentrations. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Naldemedine and Ulipristal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain and diarrhea; no dose adjustment is usually needed after a single ulipristal dose.
What other medicines interact with Naldemedine?
MediHelp also lists interactions of Naldemedine with, for example, Bupropion-naltrexone, Naltrexone, Phenytoin. The full list is on the Naldemedine page.
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