Drug interactions
Naproxen + Streptomycin
Severity: Moderate
Naproxen and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce aminoglycoside clearance, an effect described mainly in neonates. Both drugs can harm the kidney, so higher streptomycin levels could increase nephrotoxicity and ototoxicity.
What this interaction means in plain words
Naproxen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced decrease in renal prostaglandins reduces glomerular filtration and aminoglycoside elimination.
What to do
Monitor renal function and streptomycin levels, and avoid the combination in renal impairment or dehydration. Use an alternative analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Naproxen with Streptomycin?
MediHelp rates the interaction as moderate. Naproxen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce aminoglycoside clearance, an effect described mainly in neonates. Both drugs can harm the kidney, so higher streptomycin levels could increase nephrotoxicity and ototoxicity.
How serious is the interaction between Naproxen and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels, and avoid the combination in renal impairment or dehydration. Use an alternative analgesic where possible.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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