Drug interactions
Naproxen + Tenecteplase
Severity: Major
Naproxen and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a fibrinolytic that markedly increases bleeding risk, and naproxen impairs platelet function and can injure the gastric mucosa. Combined use raises the likelihood of serious hemorrhage, including gastrointestinal and intracranial bleeding.
What this interaction means in plain words
Naproxen and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naproxen belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive effects of fibrinolysis and NSAID-induced reversible platelet inhibition and mucosal injury.
What to do
Avoid starting NSAIDs around thrombolysis unless clearly needed, and monitor closely for bleeding. Use paracetamol for analgesia where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Naproxen with Tenecteplase?
MediHelp rates the interaction as major. Naproxen and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a fibrinolytic that markedly increases bleeding risk, and naproxen impairs platelet function and can injure the gastric mucosa. Combined use raises the likelihood of serious hemorrhage, including gastrointestinal and intracranial bleeding.
How serious is the interaction between Naproxen and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting NSAIDs around thrombolysis unless clearly needed, and monitor closely for bleeding. Use paracetamol for analgesia where possible.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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