Drug interactions
Naproxen + Terazosin
Severity: Moderate
Naproxen and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of antihypertensives, which may reduce the control achieved with terazosin when used for hypertension. The effect is variable and generally modest.
What this interaction means in plain words
Naproxen and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Terazosin belongs to Genitourinary.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and fluid retention and raises vascular resistance, opposing antihypertensive action.
What to do
Monitor blood pressure when an NSAID is started, continued long term or stopped. Use the lowest effective NSAID dose for the shortest time, or consider paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Naproxen with Terazosin?
MediHelp rates the interaction as moderate. Naproxen and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of antihypertensives, which may reduce the control achieved with terazosin when used for hypertension. The effect is variable and generally modest.
How serious is the interaction between Naproxen and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is started, continued long term or stopped. Use the lowest effective NSAID dose for the shortest time, or consider paracetamol.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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