Drug interactions
Naproxen + Timolol
Severity: Moderate
Naproxen and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use may reduce the blood pressure-lowering effect of beta-blockers. Systemic exposure to timolol is relevant with oral use and can be significant with eye drops in some patients.
What this interaction means in plain words
Naproxen and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin synthesis leads to sodium and water retention and reduced vasodilation, opposing beta-blocker antihypertensive action.
What to do
Monitor blood pressure when naproxen is taken regularly with oral timolol and adjust therapy if control worsens. Use the shortest NSAID course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Naproxen with Timolol?
MediHelp rates the interaction as moderate. Naproxen and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use may reduce the blood pressure-lowering effect of beta-blockers. Systemic exposure to timolol is relevant with oral use and can be significant with eye drops in some patients.
How serious is the interaction between Naproxen and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when naproxen is taken regularly with oral timolol and adjust therapy if control worsens. Use the shortest NSAID course possible.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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