Drug interactions
Naproxen + Tobramycin
Severity: Moderate
Naproxen and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, as reported chiefly in preterm infants. Because both can injure the kidney, tobramycin accumulation may raise nephrotoxicity and ototoxicity risk.
What this interaction means in plain words
Naproxen and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins lowers glomerular filtration and so aminoglycoside clearance.
What to do
Monitor serum creatinine and tobramycin trough concentrations during combined use. Avoid or limit NSAID use in patients who are dehydrated or have renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Naproxen with Tobramycin?
MediHelp rates the interaction as moderate. Naproxen and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, as reported chiefly in preterm infants. Because both can injure the kidney, tobramycin accumulation may raise nephrotoxicity and ototoxicity risk.
How serious is the interaction between Naproxen and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough concentrations during combined use. Avoid or limit NSAID use in patients who are dehydrated or have renal impairment.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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