Drug interactions
Naratriptan + Nefazodone
Severity: Moderate
Naratriptan and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity, and with a triptan it may rarely cause serotonin syndrome. Nefazodone also inhibits CYP3A4, though naratriptan is mostly renally cleared so this adds little.
What this interaction means in plain words
Naratriptan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from triptan agonism and nefazodone serotonin reuptake inhibition.
What to do
Monitor for serotonin syndrome symptoms after starting or adjusting either drug. Discontinue the serotonergic drugs if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Nefazodone?
MediHelp rates the interaction as moderate. Naratriptan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity, and with a triptan it may rarely cause serotonin syndrome. Nefazodone also inhibits CYP3A4, though naratriptan is mostly renally cleared so this adds little.
How serious is the interaction between Naratriptan and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms after starting or adjusting either drug. Discontinue the serotonergic drugs if suspected.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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