Drug interactions
Naratriptan + Netupitant / palonosetron
Severity: Moderate
Naratriptan and Netupitant / palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palonosetron has rarely been associated with serotonin syndrome when given with serotonergic drugs such as triptans. The risk is low and largely theoretical. No important pharmacokinetic interaction is expected.
What this interaction means in plain words
Naratriptan and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect; the mechanism is not well established.
What to do
Monitor for serotonin syndrome features such as agitation, tremor, sweating and clonus. Stop the agents and treat if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Netupitant / palonosetron?
MediHelp rates the interaction as moderate. Naratriptan and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palonosetron has rarely been associated with serotonin syndrome when given with serotonergic drugs such as triptans. The risk is low and largely theoretical. No important pharmacokinetic interaction is expected.
How serious is the interaction between Naratriptan and Netupitant / palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome features such as agitation, tremor, sweating and clonus. Stop the agents and treat if symptoms arise.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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