Drug interactions
Naratriptan + Olanzapine
Severity: Minor
Naratriptan and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect serotonergic signalling, and combined use has been associated with a theoretical risk of serotonin syndrome. The reported risk is low, and the clinical significance is uncertain.
What this interaction means in plain words
Naratriptan and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naratriptan belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects from 5-HT1B/1D agonism and olanzapine 5-HT2A antagonism; mechanism not firmly established.
What to do
Counsel patients to report agitation, tremor, fever, sweating or muscle rigidity. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Olanzapine?
MediHelp rates the interaction as minor. Naratriptan and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs affect serotonergic signalling, and combined use has been associated with a theoretical risk of serotonin syndrome. The reported risk is low, and the clinical significance is uncertain.
How serious is the interaction between Naratriptan and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, fever, sweating or muscle rigidity. No routine dose adjustment is needed.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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