Drug interactions
Naratriptan + Pimozide
Severity: Minor
Naratriptan and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans have serotonergic activity and antipsychotics can alter serotonin signalling, so serotonin syndrome has been theorised with this combination. Real-world risk appears low, and naratriptan is not a CYP3A4 inhibitor.
What this interaction means in plain words
Naratriptan and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naratriptan belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects via 5-HT1B/1D agonism and antipsychotic receptor modulation; the interaction is mostly theoretical.
What to do
No routine change is needed; educate the patient to report agitation, tremor, fever or diarrhea. Evaluate promptly if symptoms of serotonin toxicity appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Pimozide?
MediHelp rates the interaction as minor. Naratriptan and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triptans have serotonergic activity and antipsychotics can alter serotonin signalling, so serotonin syndrome has been theorised with this combination. Real-world risk appears low, and naratriptan is not a CYP3A4 inhibitor.
How serious is the interaction between Naratriptan and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; educate the patient to report agitation, tremor, fever or diarrhea. Evaluate promptly if symptoms of serotonin toxicity appear.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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