Drug interactions
Naratriptan + Protriptyline
Severity: Moderate
Naratriptan and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A triptan with a tricyclic antidepressant may add to serotonergic stimulation and rarely cause serotonin syndrome. Evidence is limited and the risk is low.
What this interaction means in plain words
Naratriptan and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from triptan agonism and protriptyline reuptake inhibition.
What to do
Monitor for serotonin syndrome during initiation and dose increases. Stop serotonergic drugs and provide supportive care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Protriptyline?
MediHelp rates the interaction as moderate. Naratriptan and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A triptan with a tricyclic antidepressant may add to serotonergic stimulation and rarely cause serotonin syndrome. Evidence is limited and the risk is low.
How serious is the interaction between Naratriptan and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome during initiation and dose increases. Stop serotonergic drugs and provide supportive care if symptoms appear.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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