Drug interactions
Naratriptan + Selegiline transdermal
Severity: Major
Naratriptan and Selegiline transdermal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline at antidepressant doses inhibits MAO nonselectively and can add to the serotonergic effects of triptans, raising the risk of serotonin syndrome. Naratriptan is not primarily metabolized by MAO, so exposure is less affected than with rizatriptan, but serotonergic toxicity remains a concern.
What this interaction means in plain words
Naratriptan and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects from MAO inhibition and triptan receptor agonism.
What to do
Avoid the combination where possible and choose a non-serotonergic acute migraine treatment. If used, monitor closely for serotonin syndrome and hypertension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Selegiline transdermal?
MediHelp rates the interaction as major. Naratriptan and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Transdermal selegiline at antidepressant doses inhibits MAO nonselectively and can add to the serotonergic effects of triptans, raising the risk of serotonin syndrome. Naratriptan is not primarily metabolized by MAO, so exposure is less affected than with rizatriptan, but serotonergic toxicity remains a concern.
How serious is the interaction between Naratriptan and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-serotonergic acute migraine treatment. If used, monitor closely for serotonin syndrome and hypertension.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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