Drug interactions
Naratriptan + St john's wort
Severity: Moderate
Naratriptan and St john's wort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
St John's wort has serotonergic activity and combined use with a triptan may increase the chance of serotonin syndrome. Evidence is limited and herbal content varies.
What this interaction means in plain words
Naratriptan and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from triptan agonism and St John's wort inhibition of monoamine reuptake.
What to do
Advise avoiding the herbal product during triptan use, or monitor for serotonin syndrome if combined. Stop the herb if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with St john's wort?
MediHelp rates the interaction as moderate. Naratriptan and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. St John's wort has serotonergic activity and combined use with a triptan may increase the chance of serotonin syndrome. Evidence is limited and herbal content varies.
How serious is the interaction between Naratriptan and St john's wort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding the herbal product during triptan use, or monitor for serotonin syndrome if combined. Stop the herb if symptoms occur.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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