Drug interactions
Naratriptan + Sufentanil sl
Severity: Moderate
Naratriptan and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity have been linked to serotonin syndrome when given with triptans. Sufentanil has weaker serotonergic activity than agents such as tramadol or meperidine, so the risk is probably low but not zero.
What this interaction means in plain words
Naratriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects (5-HT1B/1D agonism with opioid-related serotonergic activity).
What to do
If both are needed, observe for mental status change, clonus, hyperthermia and autonomic instability, especially at initiation or dose increases. Stop one or both agents if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Sufentanil sl?
MediHelp rates the interaction as moderate. Naratriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids with serotonergic activity have been linked to serotonin syndrome when given with triptans. Sufentanil has weaker serotonergic activity than agents such as tramadol or meperidine, so the risk is probably low but not zero.
How serious is the interaction between Naratriptan and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, observe for mental status change, clonus, hyperthermia and autonomic instability, especially at initiation or dose increases. Stop one or both agents if serotonin syndrome is suspected.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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