Drug interactions
Naratriptan + Venlafaxine
Severity: Moderate
Naratriptan and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so serotonin syndrome is a possible but uncommon complication. The combination is frequently used in practice.
What this interaction means in plain words
Naratriptan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from serotonin-norepinephrine reuptake inhibition and 5-HT1B/1D agonism.
What to do
Counsel the patient on early signs of serotonin toxicity and to seek care if they occur. Use the lowest effective triptan dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Venlafaxine?
MediHelp rates the interaction as moderate. Naratriptan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so serotonin syndrome is a possible but uncommon complication. The combination is frequently used in practice.
How serious is the interaction between Naratriptan and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on early signs of serotonin toxicity and to seek care if they occur. Use the lowest effective triptan dose.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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