Drug interactions
Natalizumab + Olaparib
Severity: Moderate
Natalizumab and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib can cause cytopenias including neutropenia, and natalizumab impairs immune surveillance. Combined use may raise the risk of serious or opportunistic infections.
What this interaction means in plain words
Natalizumab and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Natalizumab belongs to Gastrointestinal Tract; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression through different pharmacodynamic mechanisms.
What to do
Monitor blood counts and watch for infection or new neurological symptoms. Reassess the need for natalizumab if prolonged cytopenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Natalizumab
- Natalizumab + Vedolizumab Contraindicated
- Axicabtagene ciloleucel + Natalizumab Major
- Baricitinib + Natalizumab Major
- Belatacept + Natalizumab Major
- Brexucabtagene autoleucel + Natalizumab Major
- Cabazitaxel + Natalizumab Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Natalizumab with Olaparib?
MediHelp rates the interaction as moderate. Natalizumab and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib can cause cytopenias including neutropenia, and natalizumab impairs immune surveillance. Combined use may raise the risk of serious or opportunistic infections.
How serious is the interaction between Natalizumab and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection or new neurological symptoms. Reassess the need for natalizumab if prolonged cytopenia occurs.
What other medicines interact with Natalizumab?
MediHelp also lists interactions of Natalizumab with, for example, Vedolizumab, Axicabtagene ciloleucel, Baricitinib. The full list is on the Natalizumab page.
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