Drug interactions
Nateglinide + Nelfinavir
Severity: Moderate
Nateglinide and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors are associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of antidiabetic therapy. Nateglinide control may therefore worsen during nelfinavir treatment.
What this interaction means in plain words
Nateglinide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-induced insulin resistance and impaired glucose metabolism.
What to do
Monitor blood glucose and HbA1c after starting nelfinavir and increase or add antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nateglinide with Nelfinavir?
MediHelp rates the interaction as moderate. Nateglinide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors are associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of antidiabetic therapy. Nateglinide control may therefore worsen during nelfinavir treatment.
How serious is the interaction between Nateglinide and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting nelfinavir and increase or add antidiabetic therapy if control deteriorates.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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