Drug interactions
Nateglinide + Nilotinib
Severity: Moderate
Nateglinide and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2C9 and CYP3A4 in vitro and could raise nateglinide exposure. This may increase glucose lowering and the risk of hypoglycemia, although clinical data are limited. Nilotinib also commonly affects glucose levels.
What this interaction means in plain words
Nateglinide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP2C9 and CYP3A4, potentially reducing nateglinide metabolism.
What to do
Monitor blood glucose after starting nilotinib and reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nateglinide with Nilotinib?
MediHelp rates the interaction as moderate. Nateglinide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP2C9 and CYP3A4 in vitro and could raise nateglinide exposure. This may increase glucose lowering and the risk of hypoglycemia, although clinical data are limited. Nilotinib also commonly affects glucose levels.
How serious is the interaction between Nateglinide and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting nilotinib and reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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