Drug interactions
Nateglinide + Pseudoephedrine
Severity: Minor
Nateglinide and Pseudoephedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sympathomimetics such as pseudoephedrine can raise blood glucose, which may partly offset the glucose-lowering effect of nateglinide. The effect is usually modest and short-lived at decongestant doses.
What this interaction means in plain words
Nateglinide and Pseudoephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nateglinide belongs to Endocrine; Pseudoephedrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism: adrenergic stimulation promotes glycogenolysis and gluconeogenesis, opposing insulin secretagogue action.
What to do
Monitor blood glucose when pseudoephedrine is used regularly in patients with diabetes and adjust antidiabetic therapy if glycemic control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Pseudoephedrine?
MediHelp rates the interaction as minor. Nateglinide and Pseudoephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sympathomimetics such as pseudoephedrine can raise blood glucose, which may partly offset the glucose-lowering effect of nateglinide. The effect is usually modest and short-lived at decongestant doses.
How serious is the interaction between Nateglinide and Pseudoephedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pseudoephedrine is used regularly in patients with diabetes and adjust antidiabetic therapy if glycemic control worsens.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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