Drug interactions
Nebivolol + Nitroglycerin rectal
Severity: Moderate
Nebivolol and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol blunts the reflex tachycardia caused by nitroglycerin but does not prevent its vasodilating effect, so hypotension may be greater. This can cause dizziness or syncope, although the combination is often used deliberately in angina.
What this interaction means in plain words
Nebivolol and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects; beta-blockade suppresses compensatory reflex tachycardia.
What to do
Monitor blood pressure and heart rate, and advise patients to rise slowly. Adjust nitroglycerin dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Nebivolol and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol blunts the reflex tachycardia caused by nitroglycerin but does not prevent its vasodilating effect, so hypotension may be greater. This can cause dizziness or syncope, although the combination is often used deliberately in angina.
How serious is the interaction between Nebivolol and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and advise patients to rise slowly. Adjust nitroglycerin dose if symptomatic hypotension occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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