Drug interactions
Nebivolol + Parecoxib
Severity: Moderate
Nebivolol and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib can blunt the antihypertensive effect of beta-blockers through reduced prostaglandin synthesis and sodium and fluid retention. Renal function may also be affected. Any CYP2D6 effect is not clinically established.
What this interaction means in plain words
Nebivolol and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition causing sodium and water retention that opposes beta-blocker blood pressure lowering.
What to do
Monitor blood pressure when parecoxib is used, especially beyond short courses. Use the lowest effective dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nebivolol and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Parecoxib?
MediHelp rates the interaction as moderate. Nebivolol and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib can blunt the antihypertensive effect of beta-blockers through reduced prostaglandin synthesis and sodium and fluid retention. Renal function may also be affected. Any CYP2D6 effect is not clinically established.
How serious is the interaction between Nebivolol and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when parecoxib is used, especially beyond short courses. Use the lowest effective dose for the shortest time.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
