Drug interactions
Nebivolol + Pentobarbital
Severity: Moderate
Nebivolol and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic enzymes and may lower nebivolol concentrations, reducing its blood pressure and heart rate control. Additive central depression and hypotension are also possible.
What this interaction means in plain words
Nebivolol and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic metabolizing enzymes increases nebivolol clearance.
What to do
Monitor blood pressure and heart rate and increase nebivolol dose if response is lost. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Pentobarbital?
MediHelp rates the interaction as moderate. Nebivolol and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces hepatic enzymes and may lower nebivolol concentrations, reducing its blood pressure and heart rate control. Additive central depression and hypotension are also possible.
How serious is the interaction between Nebivolol and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and increase nebivolol dose if response is lost. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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