Drug interactions
Nebivolol + Phenobarbital
Severity: Moderate
Nebivolol and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces hepatic enzymes and may lower nebivolol levels, weakening its antihypertensive and heart rate effects. Dose requirements may rise during chronic phenobarbital use and fall again after it is stopped.
What this interaction means in plain words
Nebivolol and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by phenobarbital increases nebivolol metabolism.
What to do
Monitor blood pressure and heart rate and raise nebivolol dose if needed. Reduce dose again if phenobarbital is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Phenobarbital?
MediHelp rates the interaction as moderate. Nebivolol and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces hepatic enzymes and may lower nebivolol levels, weakening its antihypertensive and heart rate effects. Dose requirements may rise during chronic phenobarbital use and fall again after it is stopped.
How serious is the interaction between Nebivolol and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and raise nebivolol dose if needed. Reduce dose again if phenobarbital is discontinued.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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