Drug interactions
Nebivolol + Phenoxybenzamine
Severity: Moderate
Nebivolol and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine causes irreversible alpha-blockade and marked vasodilation, and nebivolol adds blood pressure lowering. Orthostatic hypotension may be enhanced, though beta-blockade is often used deliberately with alpha-blockade in pheochromocytoma.
What this interaction means in plain words
Nebivolol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha- and beta-adrenergic blockade.
What to do
Start alpha-blockade before beta-blockade where treating pheochromocytoma, and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Nebivolol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine causes irreversible alpha-blockade and marked vasodilation, and nebivolol adds blood pressure lowering. Orthostatic hypotension may be enhanced, though beta-blockade is often used deliberately with alpha-blockade in pheochromocytoma.
How serious is the interaction between Nebivolol and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start alpha-blockade before beta-blockade where treating pheochromocytoma, and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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