Drug interactions
Nebivolol + Pirbuterol
Severity: Moderate
Nebivolol and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is a beta-blocker with high beta-1 selectivity, and it can blunt the bronchodilator effect of pirbuterol. In patients with asthma or COPD this may reduce rescue inhalers' effectiveness and in sensitive patients may provoke bronchospasm.
What this interaction means in plain words
Nebivolol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors, with beta-1 selectivity lost at higher nebivolol doses.
What to do
Use the lowest effective nebivolol dose and monitor respiratory symptoms and peak flow. Consider a non-beta-blocker alternative in patients with significant reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Pirbuterol?
MediHelp rates the interaction as moderate. Nebivolol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is a beta-blocker with high beta-1 selectivity, and it can blunt the bronchodilator effect of pirbuterol. In patients with asthma or COPD this may reduce rescue inhalers' effectiveness and in sensitive patients may provoke bronchospasm.
How serious is the interaction between Nebivolol and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nebivolol dose and monitor respiratory symptoms and peak flow. Consider a non-beta-blocker alternative in patients with significant reactive airway disease.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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