Drug interactions
Nebivolol + Prazosin
Severity: Moderate
Nebivolol and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prazosin blocks alpha-1 receptors and can cause first-dose orthostatic hypotension. Adding nebivolol increases the antihypertensive effect and may blunt reflex tachycardia, raising the risk of dizziness and syncope.
What this interaction means in plain words
Nebivolol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive vasodilatory and blood pressure lowering effects from alpha-1 blockade and beta-blockade.
What to do
Start prazosin at a low dose at bedtime in patients on nebivolol and check standing blood pressure. Titrate gradually and counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Nebivolol with Prazosin?
MediHelp rates the interaction as moderate. Nebivolol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prazosin blocks alpha-1 receptors and can cause first-dose orthostatic hypotension. Adding nebivolol increases the antihypertensive effect and may blunt reflex tachycardia, raising the risk of dizziness and syncope.
How serious is the interaction between Nebivolol and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose at bedtime in patients on nebivolol and check standing blood pressure. Titrate gradually and counsel patients about orthostatic symptoms.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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