Drug interactions
Nebivolol + Quinacrine
Severity: Moderate
Nebivolol and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6 and could raise nebivolol concentrations, increasing bradycardia and hypotension risk. The interaction is predicted from mechanism rather than well documented.
What this interaction means in plain words
Nebivolol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP2D6-mediated nebivolol metabolism.
What to do
Monitor heart rate and blood pressure after starting quinacrine. Lower nebivolol dose if excessive beta-blockade appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Quinacrine?
MediHelp rates the interaction as moderate. Nebivolol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6 and could raise nebivolol concentrations, increasing bradycardia and hypotension risk. The interaction is predicted from mechanism rather than well documented.
How serious is the interaction between Nebivolol and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting quinacrine. Lower nebivolol dose if excessive beta-blockade appears.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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