Drug interactions
Nebivolol + Sacubitril / valsartan
Severity: Moderate
Nebivolol and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, and they are often combined in heart failure. Hypotension, dizziness and renal impairment can occur, particularly during titration. Sacubitril/valsartan raises potassium, whereas nebivolol has little direct effect.
What this interaction means in plain words
Nebivolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects; angiotensin receptor blockade may raise potassium.
What to do
Monitor blood pressure, renal function and potassium during initiation and titration. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Nebivolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, and they are often combined in heart failure. Hypotension, dizziness and renal impairment can occur, particularly during titration. Sacubitril/valsartan raises potassium, whereas nebivolol has little direct effect.
How serious is the interaction between Nebivolol and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium during initiation and titration. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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