Drug interactions
Nebivolol + Sacubitril/Valsartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive antihypertensive effects may lead to symptomatic hypotension, especially during initiation or titration.
Mechanism of action
Pharmacodynamic: ARNI-mediated vasodilation combined with beta-1 blockade with vasodilatory activity lowers blood pressure.
Clinical management
Initiate and uptitrate carefully; monitor blood pressure and heart rate; adjust doses if symptomatic hypotension occurs.
Drug reference
References
- ENTRESTO (sacubitril and valsartan) Prescribing Information — FDA Label
- BYSTOLIC (nebivolol) Prescribing Information — FDA Label
Frequently asked questions
Can I take Nebivolol with Sacubitril/Valsartan?
The interaction is rated: Moderate. Additive antihypertensive effects may lead to symptomatic hypotension, especially during initiation or titration.
How serious is the interaction between Nebivolol and Sacubitril/Valsartan?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between Nebivolol and Sacubitril/Valsartan managed?
Initiate and uptitrate carefully; monitor blood pressure and heart rate; adjust doses if symptomatic hypotension occurs.
Why do Nebivolol and Sacubitril/Valsartan interact?
Pharmacodynamic: ARNI-mediated vasodilation combined with beta-1 blockade with vasodilatory activity lowers blood pressure.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.