Drug interactions
Nebivolol + Terbutaline
Severity: Moderate
Nebivolol and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is a beta-1 selective blocker that can still reduce beta-2 mediated bronchodilation at higher doses or in sensitive patients. This may weaken the response to terbutaline and may precipitate bronchospasm in asthma or COPD.
What this interaction means in plain words
Nebivolol and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors, with loss of cardioselectivity at higher doses.
What to do
Use the lowest effective nebivolol dose in patients with airway disease and monitor asthma control and heart rate. Consider whether bronchodilator needs are increasing and reassess the beta-blocker if so.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Terbutaline?
MediHelp rates the interaction as moderate. Nebivolol and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is a beta-1 selective blocker that can still reduce beta-2 mediated bronchodilation at higher doses or in sensitive patients. This may weaken the response to terbutaline and may precipitate bronchospasm in asthma or COPD.
How serious is the interaction between Nebivolol and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nebivolol dose in patients with airway disease and monitor asthma control and heart rate. Consider whether bronchodilator needs are increasing and reassess the beta-blocker if so.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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