Drug interactions
Nebivolol + Theophylline
Severity: Minor
Nebivolol and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is beta-1 selective, so bronchospasm risk is lower, but selectivity decreases at higher doses and in poor CYP2D6 metabolizers. Any antagonism of theophylline effect is modest.
What this interaction means in plain words
Nebivolol and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nebivolol belongs to Cardiovascular; Theophylline belongs to Respiratory.
Why it happens
Possible beta-2 blockade at higher doses opposing theophylline bronchodilation.
What to do
Use the lowest effective nebivolol dose and monitor respiratory symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Theophylline?
MediHelp rates the interaction as minor. Nebivolol and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nebivolol is beta-1 selective, so bronchospasm risk is lower, but selectivity decreases at higher doses and in poor CYP2D6 metabolizers. Any antagonism of theophylline effect is modest.
How serious is the interaction between Nebivolol and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nebivolol dose and monitor respiratory symptoms.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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