Drug interactions
Nebivolol + Venlafaxine
Severity: Minor
Nebivolol and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is a weak CYP2D6 inhibitor and may modestly raise nebivolol levels, mainly in extensive metabolizers. This may cause more bradycardia or hypotension, although the effect is usually small. Venlafaxine can also raise blood pressure, which may partly oppose nebivolol.
What this interaction means in plain words
Nebivolol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nebivolol belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6-mediated nebivolol metabolism by venlafaxine.
What to do
No routine dose change is needed. Monitor heart rate and blood pressure after starting or stopping venlafaxine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nebivolol and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Nebivolol with Venlafaxine?
MediHelp rates the interaction as minor. Nebivolol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Venlafaxine is a weak CYP2D6 inhibitor and may modestly raise nebivolol levels, mainly in extensive metabolizers. This may cause more bradycardia or hypotension, although the effect is usually small. Venlafaxine can also raise blood pressure, which may partly oppose nebivolol.
How serious is the interaction between Nebivolol and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor heart rate and blood pressure after starting or stopping venlafaxine.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
