Drug interactions
Nebivolol + Yohimbe
Severity: Moderate
Nebivolol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe blocks alpha-2 receptors and increases sympathetic outflow, raising blood pressure and heart rate. Nebivolol may blunt the tachycardia but does not reliably prevent hypertensive effects, and the combination is unpredictable.
What this interaction means in plain words
Nebivolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition between yohimbine-driven sympathetic activation and beta blockade.
What to do
Advise patients to avoid yohimbe-containing supplements while taking antihypertensives, and monitor blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Yohimbe?
MediHelp rates the interaction as moderate. Nebivolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe blocks alpha-2 receptors and increases sympathetic outflow, raising blood pressure and heart rate. Nebivolol may blunt the tachycardia but does not reliably prevent hypertensive effects, and the combination is unpredictable.
How serious is the interaction between Nebivolol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe-containing supplements while taking antihypertensives, and monitor blood pressure if used.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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