Drug interactions
Nefazodone + Oxaprozin
Severity: Moderate
Nefazodone and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a serotonergic antidepressant that can reduce platelet serotonin and aggregation, though its effect is weaker than that of SSRIs. With oxaprozin it may raise the risk of gastrointestinal bleeding.
What this interaction means in plain words
Nefazodone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function combined with NSAID-induced gastric mucosal injury.
What to do
Watch for signs of gastrointestinal bleeding, and consider a proton pump inhibitor in patients at higher risk. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Nefazodone with Oxaprozin?
MediHelp rates the interaction as moderate. Nefazodone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a serotonergic antidepressant that can reduce platelet serotonin and aggregation, though its effect is weaker than that of SSRIs. With oxaprozin it may raise the risk of gastrointestinal bleeding.
How serious is the interaction between Nefazodone and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of gastrointestinal bleeding, and consider a proton pump inhibitor in patients at higher risk. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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