Drug interactions
Nefazodone + Prednisone
Severity: Moderate
Nefazodone and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may raise systemic exposure to corticosteroids. Prednisone is affected to a lesser extent than methylprednisolone, but increased corticosteroid effects and adverse reactions are possible.
What this interaction means in plain words
Nefazodone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism by nefazodone reduces corticosteroid clearance.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and mood changes, and reduce the prednisone dose if they appear. Consider an alternative antidepressant for prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Nefazodone with Prednisone?
MediHelp rates the interaction as moderate. Nefazodone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may raise systemic exposure to corticosteroids. Prednisone is affected to a lesser extent than methylprednisolone, but increased corticosteroid effects and adverse reactions are possible.
How serious is the interaction between Nefazodone and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and mood changes, and reduce the prednisone dose if they appear. Consider an alternative antidepressant for prolonged use.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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