Drug interactions
Nefazodone + Procarbazine
Severity: Contraindicated
Nefazodone and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity through reuptake inhibition and 5-HT2A antagonism, and procarbazine inhibits MAO. The combination can cause serotonin syndrome with hyperthermia, rigidity, and altered mental status.
What this interaction means in plain words
Nefazodone and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition plus serotonin reuptake inhibition produces additive serotonergic effects.
What to do
Avoid the combination. Leave a washout of at least 14 days after stopping procarbazine before starting nefazodone, and the reverse.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Nefazodone with Procarbazine?
MediHelp rates the interaction as contraindicated. Nefazodone and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone has serotonergic activity through reuptake inhibition and 5-HT2A antagonism, and procarbazine inhibits MAO. The combination can cause serotonin syndrome with hyperthermia, rigidity, and altered mental status.
How serious is the interaction between Nefazodone and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Leave a washout of at least 14 days after stopping procarbazine before starting nefazodone, and the reverse.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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