Drug interactions
Nefazodone + Simvastatin
Severity: Contraindicated
Nefazodone and Simvastatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone increases simvastatin exposure and rhabdomyolysis has been reported with the combination. It is contraindicated in labeling.
What this interaction means in plain words
Nefazodone and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nefazodone is a strong CYP3A4 inhibitor that reduces simvastatin metabolism.
What to do
Avoid; use an alternative statin such as pravastatin or an antidepressant without CYP3A4 inhibition.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Nefazodone with Simvastatin?
MediHelp rates the interaction as contraindicated. Nefazodone and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone increases simvastatin exposure and rhabdomyolysis has been reported with the combination. It is contraindicated in labeling.
How serious is the interaction between Nefazodone and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use an alternative statin such as pravastatin or an antidepressant without CYP3A4 inhibition.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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