Drug interactions
Nefazodone + Sulindac
Severity: Moderate
Nefazodone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits serotonin reuptake to some extent, which can impair platelet aggregation, and sulindac adds antiplatelet effects and gastric irritation. The combination may increase the risk of bleeding, especially in the upper GI tract.
What this interaction means in plain words
Nefazodone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from reduced platelet serotonin uptake and NSAID cyclooxygenase inhibition.
What to do
Monitor for signs of GI bleeding and consider gastroprotection in high-risk patients. Prefer a non-NSAID analgesic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nefazodone and Sulindac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Nefazodone with Sulindac?
MediHelp rates the interaction as moderate. Nefazodone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits serotonin reuptake to some extent, which can impair platelet aggregation, and sulindac adds antiplatelet effects and gastric irritation. The combination may increase the risk of bleeding, especially in the upper GI tract.
How serious is the interaction between Nefazodone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider gastroprotection in high-risk patients. Prefer a non-NSAID analgesic if possible.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
