Drug interactions
Nefazodone + Sumatriptan
Severity: Moderate
Nefazodone and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits serotonin reuptake and blocks 5-HT2A receptors, and with sumatriptan it may rarely cause serotonin syndrome. Nefazodone also inhibits CYP3A4, though sumatriptan is mainly cleared by MAO-A so this has little effect.
What this interaction means in plain words
Nefazodone and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from reuptake inhibition and 5-HT1 agonism.
What to do
Monitor for signs of serotonin syndrome, especially during initiation or dose increases. Discontinue the agents if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nefazodone and Sumatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Nefazodone with Sumatriptan?
MediHelp rates the interaction as moderate. Nefazodone and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits serotonin reuptake and blocks 5-HT2A receptors, and with sumatriptan it may rarely cause serotonin syndrome. Nefazodone also inhibits CYP3A4, though sumatriptan is mainly cleared by MAO-A so this has little effect.
How serious is the interaction between Nefazodone and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially during initiation or dose increases. Discontinue the agents if toxicity develops.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
