Drug interactions
Nefazodone + Tamsulosin
Severity: Major
Nefazodone and Tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can increase tamsulosin exposure. This raises the risk of hypotension and syncope.
What this interaction means in plain words
Nefazodone and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nefazodone inhibits CYP3A4, decreasing tamsulosin clearance.
What to do
Avoid the combination and consider another antidepressant or alpha-blocker alternative. If used together, monitor orthostatic blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Nefazodone with Tamsulosin?
MediHelp rates the interaction as major. Nefazodone and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone is a strong CYP3A4 inhibitor and can increase tamsulosin exposure. This raises the risk of hypotension and syncope.
How serious is the interaction between Nefazodone and Tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider another antidepressant or alpha-blocker alternative. If used together, monitor orthostatic blood pressure.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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