Drug interactions
Nefazodone + Terbinafine
Severity: Minor
Nefazodone and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits CYP3A4 and might modestly increase terbinafine exposure. The effect is expected to be limited.
What this interaction means in plain words
Nefazodone and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nefazodone inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No dose adjustment is usually needed. Monitor for terbinafine adverse effects, and liver tests given nefazodone's hepatotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Nefazodone with Terbinafine?
MediHelp rates the interaction as minor. Nefazodone and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone inhibits CYP3A4 and might modestly increase terbinafine exposure. The effect is expected to be limited.
How serious is the interaction between Nefazodone and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for terbinafine adverse effects, and liver tests given nefazodone's hepatotoxicity.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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