Drug interactions
Nefazodone + Ticagrelor
Severity: Major
Nefazodone and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can markedly raise ticagrelor exposure. This increases the risk of bleeding and of ticagrelor-related adverse effects such as dyspnea.
What this interaction means in plain words
Nefazodone and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong inhibition of CYP3A4 by nefazodone reduces ticagrelor clearance.
What to do
Avoid the combination; labeling advises against strong CYP3A inhibitors with ticagrelor. Use a different antidepressant or another P2Y12 inhibitor such as prasugrel or clopidogrel if clinically suitable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nefazodone and Ticagrelor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Nefazodone with Ticagrelor?
MediHelp rates the interaction as major. Nefazodone and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone is a strong CYP3A4 inhibitor and can markedly raise ticagrelor exposure. This increases the risk of bleeding and of ticagrelor-related adverse effects such as dyspnea.
How serious is the interaction between Nefazodone and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against strong CYP3A inhibitors with ticagrelor. Use a different antidepressant or another P2Y12 inhibitor such as prasugrel or clopidogrel if clinically suitable.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
