Drug interactions
Nefazodone + Tranylcypromine
Severity: Contraindicated
Nefazodone and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonin reuptake inhibiting and 5-HT2A antagonist activity, and with an MAO inhibitor it can cause serotonin syndrome. Labeling contraindicates concurrent use.
What this interaction means in plain words
Nefazodone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive serotonergic effects from reuptake inhibition and impaired serotonin metabolism by MAO inhibition.
What to do
Do not co-administer. Separate by at least 14 days after stopping tranylcypromine, and at least 7 days after stopping nefazodone.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Nefazodone with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Nefazodone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone has serotonin reuptake inhibiting and 5-HT2A antagonist activity, and with an MAO inhibitor it can cause serotonin syndrome. Labeling contraindicates concurrent use.
How serious is the interaction between Nefazodone and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Separate by at least 14 days after stopping tranylcypromine, and at least 7 days after stopping nefazodone.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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